Zonula occludens toxins and their prophages in Campylobacter species
نویسندگان
چکیده
منابع مشابه
Zonula occludens toxins and their prophages in Campylobacter species
BACKGROUND We previously showed that zonula occludens toxin (Zot) encoded by Campylobacter concisus zot (808T) gene has the potential to initiate inflammatory bowel disease. This Zot protein caused prolonged intestinal epithelial barrier damage, induced intestinal epithelial and macrophage production of tumor necrosis factor-α and enhanced the responses of macrophages to other microbes. In orde...
متن کاملExamination of the effects of Campylobacter concisus zonula occludens toxin on intestinal epithelial cells and macrophages
BACKGROUND Campylobacter concisus is a Gram-negative bacterium that is associated with inflammatory bowel disease (IBD). Some C. concisus strains carry zonula occludens toxin (zot) gene which has polymorphisms. This study investigated the effects of C. concisus Zot on intestinal epithelial cells and macrophages using cell line models. METHODS Campylobacter concisus zot (808T) gene, a polymorp...
متن کاملThe Structure of the Zonula Occludens
Replicas of freeze-fractured toad urinary bladder and gallbladder were analysed in an attempt to determine the fracturing properties and structure of the zonula occludens (tight junction). Chalcroft and Bullivant have proposed that the junction has a double set of fibrils with one set associated with each of the adjacent cell membranes. However, the fracturing pattern that is observed might als...
متن کاملRole of claudin species–specific dynamics in reconstitution and remodeling of the zonula occludens
Tight-junction strands, which are organized into the beltlike cell-cell adhesive structure called the zonula occludens (TJ), create the paracellular permselective barrier in epithelial cells. The TJ is constructed on the basis of the zonula adherens (AJ) by polymerized claudins in a process mediated by ZO-1/2, but whether the 24 individual claudin family members play different roles at the TJ i...
متن کاملThe Dual Role of Zonula Occludens (ZO) Proteins
ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In addition, they provide a link between the integral membrane proteins and the filamentous cytoskeleton. ZO proteins belong to the large family of membrane-associated guanylate kinase (MAGUK)-like proteins compr...
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ژورنال
عنوان ژورنال: Gut Pathogens
سال: 2016
ISSN: 1757-4749
DOI: 10.1186/s13099-016-0125-1